A 45-Year-Old Man Comes to the Office for Progressive Weakness

A 45-year-old man comes to the office for progressive weakness and fatigue over the last year.  The patient was adopted and does not know his family history.  After a comprehensive physical examination and laboratory evaluation, the patient undergoes genetic testing.  A loss of expression mutation is identified in a gene coding for a protein found on the basolateral surface of hepatocytes and enterocytes.  The protein is known to interact with the transferrin receptor.  Which of the following conditions is this patient at greatest risk of developing?

A) Basal ganglia atrophy
B) Fat malabsorption and osteoporosis
C) Iron deficiency anemia
D) Liver cirrhosis and hepatocellular carcinoma
E) Pulmonary emphysema

Correct Answer:

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