A 23-Year-Old Man Comes to the Office Due to a Rapidly

A 23-year-old man comes to the office due to a rapidly enlarging left jaw mass that has developed over the past several weeks.  The patient is a political refugee from East Africa.  He has no known medical problems and takes no medications.  Temperature is 37.1 C (98.8 F) .  Physical examination shows a large left-sided tumor on his jaw with surrounding lymphadenopathy but no erythema or warmth.  The rest of the examination is unremarkable.  HIV testing is negative.  The lesion is biopsied, and numerous mitotic figures and apoptotic bodies are observed on histopathologic examination.  Which of the following genetic features is most likely to be present in this tissue?

A) BCL2 overexpression
B) BCR-ABL rearrangement
C) c-Myc oncogene overexpression
D) n-Myc oncogene overexpression
E) Tyrosine kinase activation

Correct Answer:

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