A 65-Year-Old Man Is Found to Have Iron Deficiency Anemia

A 65-year-old man is found to have iron deficiency anemia.  He has had no cough, abdominal pain, melena, or change in bowel habits but reports anorexia and a 5-kg (11-lb) weight loss in the past 2 months.  Cardiopulmonary and abdominal examinations are unremarkable.  Rectal examination shows guaiac-positive brown stool.  A 3-cm mass is found on colonoscopy.  Biopsy shows pleomorphic cells with large, dark nuclei forming irregular, crowded glands, some of which contain mucus.  Imaging studies reveal multiple mass lesions in the liver and lungs.  This patient's neoplasm most likely originated from which of the following locations?

A) Adrenal gland
B) Ascending colon
C) Lungs
D) Prostate
E) Rectosigmoid colon

Correct Answer:

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