A Novel Antimicrobial Agent That Inhibits Bacterial Glycosyltransferase Enzyme Is

A novel antimicrobial agent that inhibits bacterial glycosyltransferase enzyme is developed.  Bacteria grown in a medium containing this antibiotic become spherical, cease to grow, and subsequently lyse.  So that the activity of this antibiotic against various bacteria can be determined, disks enriched with the drug are placed on agar plates containing bacterial colonies.  The plates are incubated alongside control plates with the same organisms but no antimicrobial disks.  The control plates all show organism growth.  In the plates with the diffusion disks, resistance to the drug is determined by measuring the zone of complete growth inhibition around the disk.  Which of the following bacteria is most likely to be resistant to this drug?

A) Actinomyces israelii
B) Borrelia burgdorferi
C) Helicobacter pylori
D) Mycoplasma hominis
E) Pasteurella multocida

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