A 43-Year-Old Immigrant from Southern Asia Suffers from a Cough

A 43-year-old immigrant from Southern Asia suffers from a cough that has lasted for several months duration.  He comes to the clinic today because of recent onset hemoptysis.  On further evaluation, he reports a 15-lb weight loss over the past four months.  Sputum cultures grow acid-fast bacilli that are susceptible to most antimycobacterial drugs in vitro.  Isoniazid monotherapy in this patient would most likely result in:

A) Bacteriocidal effect on only extracellular bacilli
B) Decreased transport protein expression on the cell surface
C) β-lactamase induction within bacterial cells
D) Rapid mycobacterial elimination from the body
E) Selective survival of bacterial cells secondary to gene mutation

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