A 47-Year-Old Man Comes to the Office Due to Persistent

A 47-year-old man comes to the office due to persistent fever, night sweats, and fatigue.  Thorough evaluation yields a diagnosis of chronic myeloid leukemia.  While undergoing treatment for his malignancy, the patient experiences headaches, scant nasal discharge, and left eye symptoms.  Physical examination reveals tenderness over the paranasal sinuses and left-sided orbital swelling and cellulitis.  Mild proptosis and ptosis of the left eye are also present.  Biopsy of the sinus mucosa is shown in the image below: Which of the following is the most likely cause of this patient's condition?

A) Aspergillus fumigatus
B) Blastomyces dermatitidis
C) Candida albicans
D) Coccidioides immitis
E) Cryptococcus neoformans
F) Histoplasma capsulatum
G) Malassezia furfur
H) Microsporum canis
I) Rhizopus species
J) Sporothrix schenckii

Correct Answer:

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