A 43-Year-Old Man Comes to the Emergency Department Due to 2

A 43-year-old man comes to the emergency department due to 2 weeks of intermittent fevers, malaise, and headaches.  He has a history of HIV and has not been taking his antiretroviral drugs recently.  Five years ago, the patient spent a year in jail.  Temperature is 38.2 C (100.8 F) .  Cerebrospinal fluid (CSF) analysis shows markedly elevated protein and low glucose, and CSF cultures grow Mycobacterium tuberculosis.  Resistance testing shows the following: Which of the following best explains the resistance pattern seen in these bacteria?

A) Altered structure of bacterial ribosomal proteins
B) Altered structure of enzymes involved in DNA winding-unwinding
C) Altered structure of enzymes involved in RNA synthesis
D) Decreased activity of bacterial catalase-peroxidase
E) Increased activity of enzymes involved in cell wall polysaccharide synthesis

Correct Answer:

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