Researchers Studying Fungal Pathogens Isolated an Ergosterol Biosynthetic Gene by Polymerase

Researchers studying fungal pathogens isolated an ergosterol biosynthetic gene by polymerase chain reaction.  Using homologous recombination, they then developed a new strain of Candida with a mutated allele for that gene.  The mutant strain was cultured in the presence of several different antifungal agents.  Compared to isolates from the wild-type strain, isolates from the mutant Candida strain exhibited enhanced growth in the presence of drug X.  Further investigation revealed that the mechanism of resistance to drug X was a decrease in ergosterol incorporation into the cell membrane.  Based on this data, drug X is likely to be most closely related to which of the following antifungal agents?

A) Caspofungin
B) Cyclosporine
C) Flucytosine
D) Griseofulvin
E) Nystatin

Correct Answer:

Verified

Unlock this answer now
Get Access to more Verified Answers free of charge

Access For Free