A Pharmaceutical Researcher Is Trying to Develop a Vaccine Against

A pharmaceutical researcher is trying to develop a vaccine against the hepatitis C virus.  She infects a chimpanzee with hepatitis C virus of known genotype and subtype.  Several weeks later, a liver sample is obtained, and viral RNAs are extracted from the hepatocytes.  A genetic study of the viral genomes reveals that the extracted RNA sequences vary significantly from that of the original infecting virus.  This genetic instability is most likely due to the lack of which of the following features during the viral replication process?

A) 3' → 5' exonuclease activity
B) 5' → 3' exonuclease activity
C) Glycosylase activity
D) Ligase activity
E) Nucleotide specificity
F) Primase activity

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