A 37-Year-Old Woman Is Evaluated for Progressive Shortness of Breath

A 37-year-old woman is evaluated for progressive shortness of breath and dry cough.  The patient has seasonal allergies and takes no medications.  There is no significant family history.  On physical examination, the lungs are clear to auscultation.  Chest imaging studies reveal pulmonary infiltrates and hilar adenopathy.  The patient undergoes lung biopsy; the findings are shown below. Which of the following sets of immune cells and cytokines is most likely responsible for the development of this patient's pathologic findings?

A) Th1, IL-2, interferon-γ
B) Th1, IL-5, IL-10
C) Th2, IL-3, interferon-γ
D) Th2, IL-4, IL-5
E) Th2, IL-5, tumor necrosis factor-alpha

Correct Answer:

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