A 4-Year-Old Boy Is Brought to the Office Due to a Progressively

A 4-year-old boy is brought to the office due to a progressively worsening cough for the past 2 days that is productive of yellow sputum.  A year ago, he was found to have bilateral lower-lobe pulmonary infiltrates on chest x-ray and was diagnosed with pneumonia.  The patient has since had 2 additional episodes of pneumonia, each requiring antibiotics for improvement of symptoms.  His current chest x-ray again reveals bilateral lower lobe infiltrates.  Further testing shows a high chloride content in his sweat.  Which of the following abnormalities is most likely to be seen in this patient?

A) Abnormal post-translational processing of a transmembrane protein
B) Decreased transcription of a transmembrane protein
C) Increased conductivity of a transmembrane chloride channel
D) Presence of a truncated transmembrane protein on the cell surface
E) Transmembrane protein with increased regulatory response to cAMP and ATP

Correct Answer:

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