A 58-Year-Old Man Comes to the Office with a Persistent

A 58-year-old man comes to the office with a persistent dry cough.  He has experienced an involuntary weight loss of 10 kg (22 lb) over the last 3 months.  The patient drinks 2-3 beers daily and has a 40-pack-year smoking history.  Physical examination shows dullness to percussion over the right lower lung base.  A chest CT reveals a right-sided pleural effusion and a mass in the lower lobe of the right lung.  Transbronchial biopsy of the mass demonstrates malignant cells with large nuclei that contain prominent, round, basophilic bodies as shown below. Which of the following enzymes is most likely to function only within this basophilic region of the nucleus?

A) DNA endonuclease
B) DNA polymerase
C) RNA polymerase I
D) RNA polymerase II
E) RNA polymerase III

Correct Answer:

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