A Young Couple Has Undergone a Successful in Vitro Fertilization

A young couple has undergone a successful in vitro fertilization procedure.  The father has cystic fibrosis and the mother has a sister with cystic fibrosis.  The father as well as the mother's sister are both known to have ΔF508 mutations, but the mother's carrier status is unknown.  Before making the decision to conceive, the couple underwent extensive genetic counseling regarding the potential risks of having a child with cystic fibrosis.  The family pedigree is diagrammed below with the unborn child marked by the red arrow. What is the probability that the unborn child will have cystic fibrosis?

A) 1/16
B) 1/8
C) 1/4
D) 1/3
E) 2/3
F) 3/4

Correct Answer:

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