Researchers Studying Chronic Lymphocytic Leukemia (CLL) Observe That in Some

Researchers studying chronic lymphocytic leukemia (CLL) observe that in some patients the disease is indolent, with limited growth over more than a decade, whereas in other patients the disease is more aggressive and becomes symptomatic early on.  They find that genetic abnormalities can be detected in a majority of patients with CLL and may play a role in determining the difference between the 2 disease courses.  A clinical study is conducted with the hypothesis that individuals with CLL with trisomy of chromosome 12 have a more favorable course than individuals with other genetic changes.  Which of the following laboratory techniques would be most useful for identifying patients with this genetic abnormality?

A) Enzyme-linked immunosorbent assay
B) Flow cytometry
C) Fluorescence in situ hybridization
D) Northern blotting
E) Western blotting

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