A 13-Year-Old Girl Is Undergoing Hematologic Evaluation

A 13-year-old girl is undergoing hematologic evaluation.  She is found to have a hemoglobin mutation that changes the partial pressure of oxygen at which hemoglobin is 50% saturated to 20 mm Hg.  In comparison, normal hemoglobin becomes 50% saturated with oxygen at 26 mm Hg.  Which of the following sequelae is this patient most likely to develop as a result of her mutation?

A) Erythrocytosis
B) Hypoxia-induced hemolysis
C) Increased erythrocyte osmotic fragility
D) Megaloblastic erythrocyte changes
E) Oxidant-induced hemolysis

Correct Answer:

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