A 24-Year-Old Man Is Evaluated for Episodic Anemia, Jaundice, and Dark

A 24-year-old man is evaluated for episodic anemia, jaundice, and dark urine.  These episodes typically occur after the use of certain drugs or following infection.  Additional history reveals that he has a brother who experiences similar episodes.  Peripheral blood smear reveals red blood cells with the findings shown below. Deficiency of which of the following enzymes would most likely result in a condition similar to this patient's presentation?

A) Bisphosphoglycerate mutase
B) Glutathione reductase
C) Hexokinase
D) Pyruvate kinase
E) Transketolase

Correct Answer:

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