A 55-Year-Old, Previously Healthy Man Is Brought to the Office

A 55-year-old, previously healthy man is brought to the office by his wife after being forced into early retirement due to poor work performance.  The patient was a financial planner but began missing important deadlines and mismanaging his client's accounts 6 months ago.  He became more irritable during this time and started to curse at and insult his coworkers when they expressed concern about his performance.  The patient has also become verbally abusive toward his wife but appears indifferent to the hurt he causes.  She has had to take over the finances and grocery shopping.  She adds, "My husband has developed quite the sweet tooth.  He eats almost two boxes of cookies a day now."  Physical examination is unremarkable.  This patient is most likely to have which of the following neuropathologic findings?

A) Aggregations of phosphorylated tau protein
B) Cytoplasm inclusions with alpha synuclein
C) Cytosolic vacuolation of neurons and glia with prion inclusions
D) Extracellular deposition of beta-amyloid
E) Intracellular deposition of presenilin

Correct Answer:

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