A 63-Year-Old Male,post Head Trauma,is Intubated and Has Been Mechanically $\mu$

A 63-year-old male,post head trauma,is intubated and has been mechanically ventilated for 78 hours.The respiratory therapist notes the following during ICU rounds: partial pressure of oxygen in the arteries (PₐO₂) is 82 mm Hg on 60% supplemental oxygen with a positive end-expiratory pressure (PEEP) of 8 cm H₂O; static compliance is averaging 38-41 cm H₂O/L; breath sounds are diminished bilaterally.Bronchoalveolar lavage (BAL) results are pending,but MRSA is suspected.Chest radiograph shows bilateral,patchy infiltrates.Patient has a temperature of 38.8° C,and the most recent white blood cell (WBC) count is 11,300 $\mu$ L.The most appropriate recommendation for this patient is which of the following?

A) Monotherapy with an antipseudomonal carbepenem
B) Monotherapy with an antipseudomonal fluoroquinolone
C) Combination therapy with two types of antipseudomonal agents and vancomycin
D) Combination therapy with ampicillin/sulbactam and linezolid

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