How Are Integral Proteins Unique in Cell Membranes

How are integral proteins unique in cell membranes?

A) They have no hydrophobic portions.
B) They are weakly bound to the surface of the membrane.
C) They are only located on the inner side of a membrane.
D) They are firmly bound to the membrane and can only be released with a detergent.
E) They are completely embedded within the lipid bilayer with no exposure to the internal cell environment.

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