Why Doesn't Every Cell in the Body Respond to Every

Why doesn't every cell in the body respond to every hormone circulating in the bloodstream?

A) Each cell has a limited number of protein channels that shuttle hormones through its membrane.
B) Not all hormones can diffuse through all cell membranes.
C) The concentration of some hormones is too low to stimulate every cell.
D) Each cell has specific surface receptors, which interact only with hormones that they recognize.
E) Although all hormones bind to all cell surfaces, some cells lack second messengers for expression.

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