COX-2 Inhibitors Like Vioxx Control Inflammation Without Affecting COX-1, but Patients

COX-2 inhibitors like Vioxx control inflammation without affecting COX-1, but patients taking these drugs are more susceptible to heart attack and stroke. Which of the following is a possible explanation of this side effect?

A) These newer COX-2 inhibitors must still interact with COX-1.
B) In creating these specific COX-2 inhibitors, scientists have changed the shape of aspirin so much that it no longer interacts with COX-2 at all.
C) In addition to controlling fever and inflammation, COX-2 plays a role in the maintaining the proper function of the circulatory system (heart and blood) .
D) Inhibiting both COX-1 and COX-2 is necessary to prevent inflammation.

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