How Is the Development of Autoimmunity Normally Prevented

How is the development of autoimmunity normally prevented?

A) T lymphocytes that respond to autoantigens in the thymus undergo clonal deletion.
B) T lymphocytes require a specific set of cytokine signals to become activated.
C) Regulatory T cells suppress autoimmune responses.
D) Clonal deletion of T cells and regulatory T cell suppression prevent autoreactive T cell activation.
E) Clonal deletion of T cells, lack of necessary cytokine signals, and regulatory T cell suppression prevent activation of autoreactive T cells.

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