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What Is the Fundamental Defect That Results in Beta-Thalassemia Major

Question 35

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What is the fundamental defect that results in beta-thalassemia major?


A) The spleen prematurely destroys the precipitate-carrying cells.
B) A severe uncoupling of a- and b-chain synthesis occurs.
C) All four beta-forming genes are defective.
D) Hemoglobin H (HbH) develops when three genes are defective.

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