Is Antigenic Shift Alone Likely to Lead to Influenza Pandemics

Is antigenic shift alone likely to lead to influenza pandemics?

A) Yes. ONLY antigenic shift can lead to the large-scale mixing of gene elements required to produce a pandemic flu strain.
B) Perhaps, but it would most likely be a mixture of antigenic shift AND drift that would result in a pandemic strain.
C) No. ONLY antigenic DRIFT can lead to the large-scale mixing of gene elements required to produce a pandemic flu strain.
D) No. Antigenic SHIFT is responsible for changes in the hemagglutinin protein, while antigenic DRIFT is responsible for changes in the neuraminidase protein. You need both to lead to a pandemic strain.
E) No. Antigenic SHIFT is responsible for changes in the neuraminidase  protein, while antigenic DRIFT is responsible for changes in the hemagglutinin protein. You need both to lead to a pandemic strain.

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