What Is a Physical/clinical Sign That a Person's Immune System

What is a physical/clinical sign that a person's immune system is involved in the proliferation of T cells in response to an infection?

A) The skin is reddened.
B) The lymph nodes in the region of the infection become enlarged.
C) The skin is bruised in the infected region.
D) The lymph nodes shrink because they are secreting so much material.
E) The temperature of the infected region decreases.

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