How Is Estradiol Recognized by the Estrogen Receptor

How is estradiol recognized by the estrogen receptor?

A) The molecular weight is recognized.
B) The atom types in the ligands are recognized by the receptors.
C) Single bonds, double bonds, and triple bonds are recognized by receptors.
D) Receptors recognize ligands by shape only.
E) Ligands are recognized by shape and intermolecular forces.

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