Xeroderma Pigmentosum (XP)is a Rare Autosomal Recessive Disorder

Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder.Patients with XP exhibit a cellular hypersensitivity to ultraviolet (UV) radiation,a high incidence of skin cancer and premature aging.Based on these clinical characteristics,what is the most likely cause for this disease?

A) defects in DNA repair
B) defects in DNA replication
C) lack of telomerase activity
D) shortened telomeres

Correct Answer:

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