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A Type-A Person Demonstrates a 3+ Reactivity with A1 Cells

Question 51

Multiple Choice

A type-A person demonstrates a 3+ reactivity with A1 cells (reverse grouping) . The forward grouping with anti-A is 4+. Therefore, the possibility of a subgroup is excluded. B cells demonstrate a 4+ reaction. The antibody screen is weakly positive at 37°C but shows no reactivity at the AHG phase. An antibody panel is performed and anti-M is identified. The patient phenotypes negative for M antigen. How is the ABO discrepancy resolved?


A) Perform reverse grouping at 4°C.
B) Perform reverse grouping with A1 cells negative for M antigen.
C) Perform reverse grouping with A1 cells positive for M antigen.
D) Perform forward grouping at 4°C.

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