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A Mutation in The β\beta Subunit of Hemoglobin Is Discovered That Reduces the Affinity of That

Question 79

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A mutation in the β\beta subunit of hemoglobin is discovered that reduces the affinity of 2,3-BPG binding. Which of the following mutations is most likely to have this consequence?


A) Val1 →\rightarrow Ile1
B) Asp99 →\rightarrow Glu99
C) Lys82 →\rightarrow Asp82
D) Glu6 →\rightarrow Val6

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