"Original Antigenic Sin" Is Best Described as a Phenomenon in Which

"Original antigenic sin" is best described as a phenomenon in which _____.

A) a highly mutable virus gradually escapes from immunological memory and interferes with compensatory immune responses.
B) latent viruses periodically activate effector T cells specific for the original antigen recognized in the primary immune response.
C) the persistence of antigen is necessary to sustain maintenance of immunological memory.
D) memory T cells no longer express the same profile of adhesion molecules and cytokine receptors compared with the original profile of the naive precursor T cell.

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