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A Chemical Compound Has Been Used as a Rodent Poison

Question 46

Multiple Choice

A chemical compound has been used as a rodent poison for many years although scientists do not know specifically how it causes death.Recently the compound was shown to bind to the dihydropyridine (DHP) receptor.What would be the best question to ask next in continued research about the mechanism of this compound?


A) Does the compound interfere with depolarization of T tubules?
B) Does the compound interfere with the binding of calcium to troponin?
C) Does the compound inhibit an action potential from developing in the muscle cell membrane and traveling down the T tubules in response to a nerve impulse?
D) Does the compound prevent calcium release from the sarcoplasmic reticulum into the sarcoplasm following a nerve impulse?
E) Does the compound prevent cross-bridge release between actin and myosin to allow a new cycle of contraction?

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