How Do Graded Changes in Membrane Potential Give Rise to All-Or-None

How do graded changes in membrane potential give rise to all-or-none changes that generate action potentials?

A) The membrane recognizes only action potentials generated by positive ions,causing a voltage threshold to be reached.
B) The membrane recognizes only action potentials generated by negative ions,causing a voltage threshold to be reached.
C) Many graded potentials at different points along the membrane are summed,causing the voltage threshold to be reached.
D) Many graded potentials reaching the same point on the membrane are summed,causing the voltage threshold to be reached.
E) The membrane allows only voltage-gated channels to open and close,enabling an electrical charge gradient to be created.

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